Creatine vs Carnitine: two supplements, two different roles

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Creatine vs Carnitine:
two supplements, two different roles

In the vast world of fitness and wellness supplements, two oft-heard names are creatine and carnitine.

Both boast health benefits and improved physical performance, but they operate in very different ways.

In this article, we will explore the key differences between creatine and carnitine, offering a helpful guide to understanding which one might best suit your needs and goals.

What is Creatine and how it works

Creatine is a natural compound produced by the human body, mainly in the liver, from amino acid precursors such as glycine, arginine, and methionine. It is also present in small amounts in foods such as meat and fish.

Creatine plays a key role in the body’s energy system, providing ATP (adenosine triphosphate) for high-intensity, short-duration muscle activities, such as lifting weights or sprinting.

Taking creatine as a supplement can increase phosphocreatine stores in muscles, allowing for increased ATP production and improving performance during anaerobic exercise.

Carnitine: definition and mechanism of action

Carnitine is an amino acid composed of lysine and methionine, synthesized mainly in the liver and kidneys. It is involved in the transport of long-chain fatty acids into the mitochondria, where they are metabolized to produce energy.

Carnitine acts as a transporter, facilitating the passage of fatty acids across the inner membrane of mitochondria, where beta-oxidation and ATP production take place.

Carnitine supplements are often used to support weight loss and improve performance during prolonged physical activity because they promote energy efficiency by using fat as fuel.

Purpose and use

Although creatine is widely used by athletes to improve performance during high-intensity exercise, it can also offer benefits to nonathletic people seeking to improve strength and body composition.

For example, the elderly may benefit from taking creatine to counteract sarcopenia, the age-related loss of muscle mass, while maintaining muscle strength and function.

In addition, people on a vegetarian or vegan diet, who may have reduced creatine levels due to the absence of animal sources, may benefit from creatine supplementation to improve physical performance and support muscle health.

As for carnitine, while it is commonly associated with athletes and weight loss, it can also be useful for nonathletic individuals who wish to improve metabolic efficiency and increase energy levels.

For example, those suffering from chronic fatigue or low energy levels may benefit from taking carnitine to improve energy metabolism and combat fatigue.

In addition, carnitine can be used by those seeking to improve cardiac health, as it plays a role in lipid metabolism and maintenance of cardiac function.

Dosage and Recommendations

Typical creatine dosage is about 3 grams/day, and only for athletes 6 g/day for one month and no more.

Carnitine is usually taken in doses of 1,000 milligrams per day, preferably before exercise or along with meals.

Synergy and combinations

In some situations, the combination of creatine and carnitine could offer synergistic benefits, such as in improving complex sports performance that requires both explosive strength and aerobic endurance.


Both creatine and carnitine are popular supplements with different purposes and mechanisms of action. The choice between the two will depend on personal goals and specific needs, but both can be useful when used appropriately and with awareness of dosages and potential side effects.

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